Time-release garlic powder capsules are also being used in clinical studies.67, One resource suggests the following doses: 2 to 5 g of fresh raw garlic; 0.4 to 1.2 g of dried garlic powder; 2 to 5 mg garlic oil; 300 to 1,000 mg of garlic extract (as solid material); and 2,400 mg/day aged garlic extract (liquid).2, 110, Clinical trials have evaluated 180 mg of allicin daily for prevention for the common cold,11 and at least 5.5 g of raw garlic for the prevention of prostate cancer.49, Administer with food to prevent GI adverse reactions.2, Garlic may be used safely in pregnancy and lactation.2 In 8 breast-feeding mothers, garlic odor in breast milk peaked after 2 hours of ingestion and decreased thereafter. You should talk with your health care provider for complete information about the risks and benefits of using this product. Its traditional uses originated thousands of years ago. Often you will find just using a toothpick dipped in the Garlic oil then added to the regular dose of Carrier Oil in your palm before application is all you need. For high blood pressure: 300-1500 mg of garlic tablets taken in divided doses daily for 24 weeks has been used. A dose of this supplement contains 2,400mg of odorless garlic from 24mg concentrate in a quick-release capsule so that you can experience the potential benefits as quickly as … Garlic’s most common folk or traditional uses as a dietary supplement are for high cholesterol, heart disease, and high blood pressure. Cerner Multum™ provides the data within some of the Overview, Uses, Warnings, Side Effects, Pregnancy, Interactions, Dosage, Overdose, and Images sections. During the 1800s, physicians routinely prescribed garlic inhalation for the treatment of tuberculosis, and raw garlic applied as a poultice continues to be used by naturopaths today.2, 3, 4. Mildly heat a few drops of garlic essential oil and rub it on your affected skin with the help of a cotton pad. The lipid indices that showed significant improvement with garlic supplementation were HDL cholesterol (P = 0.003) and plasma triacylglycerols (P = 0.021). easy bruising or bleeding (nosebleeds, bleeding gums). They help to strengthen the immune system with their natural antibiotic, antimicrobial, antiseptic and antiviral properties. Garlic may be used safely in pregnancy and breast-feeding at usual doses. https://www.webmd.com/drugs/2/drug-3826/garlic-oil-oral/details The U.S. Food and Drug Administration (FDA) has not approved garlic for medicinal use and categorizes it as a food substance. Bleeding may occur. When considering the use of herbal supplements, seek the advice of your doctor. Taking a single dose of expired Garlic Oil is unlikely to produce an adverse event. Garlic is an herb sometimes used to protect against high blood pressure. Drug-induced lymphocyte stimulation test results for both black and raw garlic were positive. During the Middle Ages, physicians prescribed the herb to cure deafness. Garlic contains allicin, selenium, zinc, copper, and vitamin C, all of which are great for boosting the health of your skin. Monitor therapy.75, Nonsteroidal anti-inflammatory agents: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of nonsteroidal anti-inflammatory agents. If using a fluid extract, 4 mL daily is an appropriate dosage and 20 mL is an equivalent dose of garlic tincture. 27. Consider therapy modification.71, 72, 73, 74, Anticoagulants: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of anticoagulants. The online purchase saves your time and money and gives you good advantage. Consider therapy modification.71, 72, 73, 74, Thrombolytic agents: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of thrombolytic agents. However, consumption by breast-feeding mothers may impact the infant's behavior during breast-feeding, causing prolonged attachment to the breast and increased sucking. Crude garlic fed to rats for 30 days resulted in decreased testosterone secretion and altered spermatogenesis.89 A case report documents severe anemia and hypertension from toxic erythrocyte hemolysis in a dog that ingested baked garlic.37. C-reactive protein levels compared with baseline were reduced in the treatment group, and higher than baseline in the placebo group. Garlic was valued as an exchange medium in ancient Egypt; its virtues were described by inscriptions on the Great Pyramid of Cheops. Stop using garlic and call your healthcare provider at once if you have: Common side effects (especially when eating raw garlic) may include: This is not a complete list of side effects and others may occur. Do not use in larger or smaller amounts or for longer than recommended. You can place the order online and you will get the packet. Medically reviewed by Drugs.com. No significant changes were noted between groups for plasma lipids or lipoproteins.106 Administration of aged garlic extract (2,400 mg/day) for 1 year significantly reduced low-attenuation plaque (LAP) in the coronary arteries of adults with metabolic syndrome compared to placebo in a double-blind, randomized controlled trial (n = 55). Garlic can affect blood-clotting and may increase your risk of bleeding. Recently after moving into our new house; I got a spider bite of some kind. Heterogeneity exists among trials, as well as poor methodology and a lack of standardization of preparations. When the bulb is ground, the enzyme allinase is released, resulting in the conversion of alliin to 2-propenesulfenic acid, which dimerizes to form allicin, and which further decomposes to diallyl sulfide, -disulfide, -trisulfide, and sulfur dioxide. Swallow it whole. Known allergy to garlic and its constituents exists. If you choose to use garlic, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. Research reveals no relevant animal data regarding the use of garlic as an antithrombotic agent. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. Total plaque volume, dense calcium, and noncalcified plaque were not significantly affected.110, A systematic review and meta-analysis of randomized controlled trials investigating the effect of garlic preparations on lipoprotein(a), Lp(a), was conducted in trials published through March 10, 2015. The bulb is odiferous and contains outer layers of thin sheathing leaves surrounding an inner sheath that encloses the clove. Consider therapy modification.76, 77, 78, 79, Salicylates: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of salicylates. Although edible, it is regarded as unpalatable and has a pungent odor. A total of 600 to 1,200 mg a day of aged garlic extract divided into a few doses throughout the day may provide protective health effects. For high blood pressure: 300-1500 mg of garlic tablets taken in divided doses daily for 24 weeks has been used. Clinical significance of less than a 4 mm Hg reduction is questionable. Have I had experience with Garlic Oil? Although the meta-analysis did not show a significant change in plasma Lp(a) levels after garlic consumption, subanalysis of trials based on duration of therapy identified a significant improvement in Lp(a) in trials lasting longer than 12 weeks (P < 0.001). Most studies on garlic use a dosage range of 600-1,200mg a day, usually divided into multiple doses. No hard outcomes data from the study period were reported.96, In South Korean patients with mild hepatic dysfunction and an elevated gamma-glutamyl transpeptidase (GGT), administration of fermented garlic extract (1.5 g/day) for 12 weeks provided a significant decrease in GGT compared to controls but only in the subgroup of patients who consumed alcohol in the 6 weeks prior to the study (P=0.015). The mean age of patients in all but 1 study ranged from 53 to 60 years who were mildly hypercholesterolemic and/or at moderate to high risk for coronary artery disease; 1 study enrolled patients 8 to 18 years of age with a positive family history. Garlic contains the highest sulfur content of any member of the genus Allium. Garlic may be used for many medical ailments or conditions that aren’t listed in this guide. Avoid taking fish oil or vitamin E while you are taking garlic. An average-sized clove of garlic contains approximately 1 gram. For healthy cholesterol and triglyceride levels Garlic supports heart health and maintains cholesterol levels. You should purchase this product only from a reliable source. Ask a doctor, pharmacist, or other healthcare provider if it is safe for you to use this product if you have: Ask a doctor before using garlic if you are pregnant or breastfeeding. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Oregano & Garlic Oil. Do not crush, chew, or break an enteric coated pill. Garlic contains approximately 0.5% of a volatile oil composed of sulfur-containing compounds (diallyldisulfide, diallyltrisulfide, methylallyltrisulfide), vinyldithiins, and ajoenes. Be sure not to take more garlic than your doctor recommends or more than is suggested on the product label. Body odor and malodorous breath are the most common complaints after garlic ingestion. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. A total of 6 trials met inclusion criteria for the meta-analysis (N = 286). Natural Powerful Conditioning Oil. Similarly, in animals given the higher dose of garlic oil (100 mg/kg body weight) the enhanced blood urea nitrogen and serum creatinine levels, which are indicative of renal injury, showed a reduction of about 30% and 40%, respectively, in comparison with the group treated with Fe-NTA alone. A double-blind, placebo-controlled study was carried out using 28 Sprague Dawley rats separated into a placebo group (16 rats) and a supplement group (12 rats). Consider therapy modification.71, 72, 73, 74, Hypoglycemic agents: Herbs (hypoglycemic properties) may enhance the hypoglycemic effect of hypoglycemic-associated agents. 2000;66(5):2269-2273. Activities of garlic oil, garlic powder, and their diallyl constituents against Helicobacter pylori. However, there are reports of inhibition of platelet aggregation and increased bleeding times in individuals ingesting garlic. American Indians used garlic as a remedy for earaches, flatulence, and scurvy. Follow the dosage set by them for the best results. This is only a brief summary of general information about this product. More side effects, mostly GI symptoms such as gastric pain and nausea, were reported in the garlic group (P < 0.01).102, Garlic juice and essential garlic oil, water, and ethanol extracts exhibit inhibitory effects in vitro on gram-positive and gram-negative bacteria, as well as fungal pathogens.2, 5, Garlic inhibited Helicobacter pylori in in vitro studies and in rodents.6, 7 Garlic has been shown to inhibit Pseudomonas aeruginosa in vitro and in animal models.8, In the an intervention trial conducted in Shandong Province, China, inhibition of H. pylori was described.6, 9 A Cochrane review found few quality trials to evaluate for garlic in the prevention of the common cold. No serious side effects were reported with garlic treatment in any of the trials.114, A case report of hypertension and hemolytic anemia in a dog that consumed baked garlic exists.37, Strong evidence for the effect of garlic on blood pressure is lacking. If you’re consuming raw garlic, dosages are usually about one to two cloves a day. The anti-inflammatory properties of the oil can help to get relief from psoriasis. Do not use different forms (cloves, tablets, oil, etc) of garlic at the same time without medical advice. Allicin gives the pungent characteristic odor to crushed garlic and is believed to be responsible for some of the pharmacologic activity of the plant.2, 3, A double-blind, randomized controlled trial in 63 menstruating women found a positive trend but no statistically significant difference in cases of vulvovaginal candidiasis in women treated for 14 days with 2.1 g/day garlic powder (19.2 g/day allicin) compared with placebo. Bleeding may occur. If you’re taking garlic for health benefits, you should aim to take between 2 to 4 grams per day. Mild GI adverse reactions (eg, bloating, flatulence, nausea) have been commonly reported with use. Garlic oil is a rich source of sulfur, vitamin E, Vitamin C, vitamin B1 and vitamin B6 which is an important nutrient for proper hair growth and scalp protection. Garlic oil - Garlic is the edible bulb from a plant in the lily family. The anti-inflammatory qualities of garlic further help relax the skin. Doses of garlic powder used in antihypertensive trials have ranged from 300 to 2,400 mg/day for up to 24 weeks. Often the bulb contains 10 to 20 cloves that are asymmetric in shape, except for those closest to the center. The double-blind, randomized, placebo-controlled study was conducted in 88 participants with uncontrolled hypertension who were administered 2 capsules daily of Kyolic aged garlic extract (1.2 g aged garlic extract powder and 1.2 mg S-allylcysteine per capsule) or placebo for 12 weeks. The optimal dosage of garlic hasn’t been established. Bleeding may occur. Studies on the effects of platelet aggregation have produced inconsistent results, possibly related to variations in study design and in the garlic preparation used. The safest option would be to consult a healthcare professional. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. It’s best to speak to a trained health professional who is skilled in complementary, integrative, or functional medicine. Call your doctor if the condition you are treating with garlic does not improve, or if it gets worse while using this product. Only 1 trial out of 5 met quality standards (adequate randomization and concealment), finding that 180 mg of allicin daily for 12 weeks resulted in a lower incidence of colds versus placebo.10 Limited clinical studies have evaluated garlic in cystic fibrosis and have found no effect on Pseudomonas aeruginosa infection or on pulmonary function.8, 10, 11, Antioxidant properties have been described, but aside from a role in cancer and hepatoprotection against chemical insult, clinical applications are lacking.25, 63, 64, 65, 66. The results were a significant reduction of 17 ±6 mg/dL in total serum cholesterol and an insignificant reduction of 9 ±6 mg/dL in the low-density lipoprotein (LDL) level. You should take the supplement one time after the meal. Use Garlic (Garlic Oil) exactly as directed on the label, or as prescribed by your doctor. None of the garlic groups had a significant reduction in SBP, with the 2-capsule group having a greater reduction than the 4-capsule group. Last updated on May 21, 2020. Subgroup analysis of a proportion of patients (50% to 60%) who were observed to respond to treatment over time revealed statistically and clinically significant average reductions of 11.5 mm Hg SBP and 6.3 mm Hg DBP compared to placebo (P < 0.001). This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. Aged garlic extract was well tolerated.113, The clinical practice guideline from the American College of Physicians/American College of Cardiology Foundation/American Heart Association/American Association for Thoracic Surgery/Preventive Cardiovascular Nurses Association/Society of Thoracic Surgeons regarding management of stable ischemic heart disease (2012) recommend that treatment with garlic, coenzyme Q10 (CoQ10), selenium, or chromium should not be used with the intent of reducing cardiovascular risk or improving outcomes in patients with stable ischemic heart disease (strong recommendation; low-quality evidence).90, A randomized, placebo-controlled trial (n = 65) of aged garlic extract plus CoQ10 showed significant improvements in vascular elasticity (pulse-wave velocity) and endothelial function (digital thermal monitor area under the temperature curve) compared with placebo after treatment for 1 year. In World War II, garlic extracts were used to disinfect wounds. Consider therapy modification.71, 72, 73, 74, Protease inhibitors: Garlic may decrease the serum concentration of protease inhibitors. The minimum effective dose for raw garlic is a single segment of a garlic bulb (called a clove), eaten with meals two or three times a day. No significant changes were seen in serum triglyceride or high-density lipoprotein levels.91 As an adjunct to conventional medical treatment, the effect of garlic powder supplementation on plasma lipids, lipoproteins, and carotid intima-media thickness (CIMT) was measured to determine cardiovascular risk and progression of atherosclerosis in patients with coronary artery disease. Garlic does not appear to lower blood glucose, cholesterol, or blood pressure by a clinically significant degree. However, platelet function does not seem to be affected.17, 21, 71, 80, 88 Hypotensive effects, Ménière disease, and myocardial infarction have also been documented.80, Based on observed pharmacologic activity, garlic should be used with caution in individuals at risk of hypotension39, 40 and hypoglycemia.27, 28, 29, In the 2016 Scientific Statement by the American Heart Association regarding drugs that may cause or exacerbate heart failure, garlic has been recognized as a product with antiplatelet activity which may increase bleeding risk when used with anticoagulants. This information relates to an herbal, vitamin, mineral or other dietary supplement. Garlic is a perennial bulb with a tall, erect flowering stem that grows up to 1 m. The leaf blade is flat, linear, solid, and approximately 1.25 to 2.5 cm wide, with an acute apex. Doses of garlic powder ranged from 300 to 2,400 mg/day for 2 to 24 weeks.109, The AGE at Heart Trial investigated the effect of aged garlic extract supplementation on blood pressure and other important risk factors of cardiovascular disease, including central blood pressure and arterial stiffness. Garlic is considered relatively nontoxic and the availability of human data makes studies in animals with dyslipidemia irrelevant. The guidance noted that naturoceuticals are not recommended for the management of heart failure symptoms or for the secondary prevention of cardiovascular events, and that nutritional supplements are not recommended for the treatment of heart failure [Low-quality; Limited].112, Information regarding the toxicology of garlic is limited. Check price at AmazonWhile other garlic supplements focus on delivering an equivalent dose of raw garlic material, Zhou Nutrition sets its priorities higher: it aims to deliver at least 5000 micrograms of allicin, the compound in garlic that many nutritionists believe is responsible for its health benefits. Garlic burns have been documented with topical use. Appl Environ Microbiol. Raw garlic, garlic powder, aged garlic extracts, or garlic oil all appear to help lower blood pressure. Because garlic is sold as an herbal supplement, there aren’t universal government manufacturing standards in place. A pilot study. This study was planned to determine the safe dose of garlic. Breast milk that smells of garlic may prolong infant attachment to the breast and increase sucking.68 A Cochrane review identified only 1 trial (100 women) showing no clear difference between garlic and placebo ingestion in preeclampsia and gestational hypertension risk, or in incidences of cesarean delivery and perinatal mortality.69 Use of garlic as an emmenagogue has been documented.70, Agents with antiplatelet properties: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of agents with antiplatelet properties. Breaking the pill will damage this coating. Skip the missed dose and take the next regularly scheduled dose. The bulbs contain an odorless, colorless, sulfur-containing amino acid named alliin (S-allyl-L-cysteine sulfoxide), which has no pharmacologic activity of its own. Do not use two doses at one time. This supplement is easily available online. It was on my underarm near my lymph node. Male wistar rats (110-170g) were fed fresh garlic homogenate (FSH) orally in three different doses (1.0, 2.5 and 5.0 g/kg body … Also, 1200 mg of garlic powder plus 3 grams of fish oil daily for 4 weeks, or 500 mg of garlic oil plus 600 mg of fish oil daily for 60 days, has been used. The most frequent side effects reported with the garlic extract was dyspepsia and gastritis.116, A cross-sectional study of dietary intake of twins found that those consuming diets high in fruits and vegetables had a lower incidence of hip OA. Non-citrus fruits and alliums had the highest protective effects.98, A Cochrane systematic review found little data on the benefit of garlic in peripheral arterial occlusive disease.